Hyaluronic Acid Guide – How It Works & How to Use It

This guide expands on the basics from the front page and is designed for people who want a deeper, more structured understanding of hyaluronic acid (HA) in skincare.

1. Hyaluronic acid in the skin vs. in skincare

In the skin, HA is part of the extracellular matrix – the “gel” that surrounds cells and collagen fibres. It helps maintain volume, flexibility and cushioning. Ageing, UV exposure and some medical conditions reduce the amount and quality of HA.

Topical HA does not magically “refill” deep skin structures, but it can meaningfully improve the hydration of the outer layers, which affects how skin looks and feels.

2. Molecular weights – why they matter

You will often see claims about “multi-molecular” or “low molecular weight” hyaluronic acid. In simplified terms:

• High MW: sits close to the surface, big plumping effect, more sticky risk.
• Low MW: can reach a bit deeper, potentially better for comfort, but may irritate reactive skin.
• Blends: combine multiple sizes to spread the effect across layers.

The exact benefits depend as much on the full formula (pH, solvents, additional humectants and occlusives) as on the HA itself.

3. Ideal partners for hyaluronic acid

• Glycerin: another humectant that plays very well with HA.
• Panthenol (vitamin B5): soothing and barrier-supporting.
• Ceramides & cholesterol: rebuild and stabilise the skin barrier.
• Occlusives (like squalane or petrolatum): help lock water in, especially at night.

For a direct comparison of HA vs glycerin, see Hyaluronic vs Glycerin.

4. Layering hyaluronic acid with actives

Because HA is generally gentle, it is often used to support stronger actives:

• With retinoids: apply HA either before or after your retinoid, then seal with moisturiser.
• With vitamin C: HA serums are often used after vitamin C in the morning to boost comfort.
• With acids (AHA/BHA): use with caution – too many humectants plus strong acids can be overwhelming for very sensitive skin.

If your routine already includes several active steps, keep your HA step simple and fragrance-free.

5. When to skip or pause hyaluronic acid

You may want to pause HA-containing products if:

• Your skin is extremely reactive and everything stings.
• You are on a “barrier reset” where you strip back to only a bland moisturiser and SPF.
• A specific HA product clearly correlates with breakouts or irritation.

When you feel ready to explore specific formulas and textures, visit Hylaronic.com for side-by-side product comparisons.